ZFIN Image: Gao et al., 2015, Fig. S6

Image

Figure Caption

Fig. S6 Bcl2 overexpression can rescue hematopoietic failure in topbp1^cas003 mutants.

(A) Quantitative analysis of HSPCs phenotype, monitored by c-myb WISH, in topbp1^cas003 mutants with or without bcl2 mRNA injection. bcl2 mRNA could significantly rescue c-myb expression in topbp1^cas003 mutants. The number of the mutant embryos (n) is indicated above each column. (B-D′) WISH of c-myb in sibling, topbp1^cas003 mutants and mutants injected with bcl2 mRNA at 4dpf. The proportion of the rescued c-myb phenotype shown in D is 25 out of 43 mutant embryos. (B′-D′) Enlarged views of the CHT representing the dashed boxes region in the left column.

Acknowledgments

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