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Fig. 1
Gene expression profiling reveals elevated inflammatory gene expression, including mmp9, in chronic inflammation mutants. (A) Microarray analysis of inflammation mutants, hi1520 and hi2217, revealed overlapping upregulation of 150 genes and downregulation of 16 genes compared with WT siblings. (B) Upregulation of mmp9 was confirmed by qRT-PCR in the hi2217 and hi1520 mutants and the hai1 morphants. (C) The mutants are characterized by epithelial extrusions and abnormal epithelium development (arrows). Data pooled from experiments performed in triplicate. *P<0.05. Scale bar: 200 µm.
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