ZFIN Image: Cruz et al., 2015, Fig. 7

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Figure Caption

Fig. 7

Selective support cell Eos activation shows non-equitable hair cell contribution during hair cell regeneration. (A) Selective support cells in adult Tg(pou4f3:gap43-GFP;actb2:NLS-Eos) caudal neuromasts were activated after neomycin treatment. Arrow indicates surviving hair cell without red nuclei. (B) Hair cell production was traced from labeled support cells during hair cell regeneration. Arrowhead illustrates hair cell with red nuclei produced from support cell with activated red Eos while the arrow illustrates a hair cell with no activated Eos protein. Scale bar, 10 µm. (C) The average red fluorescence of locally activated support cells and regenerated hair cells of 10 different neuromasts following hair cell regeneration.

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Reprinted from Developmental Biology, 402(2), Cruz, I.A., Kappedal, R., Mackenzie, S.M., Hailey, D.W., Hoffman, T.L., Schilling, T.F., Raible, D.W., Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance, 229-38, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.