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Fig. 7
Reduction in mineralized tooth size associated with hedgehog inhibition. A–C: 3D renderings of 96 hpf mineralized tooth #1 using alizarin red staining and confocal microscopy. A: 40–96 hpf EtOH treated control tooth #1. B: 48–96 hpf CyA exposed tooth. C: 40–96 hpf CyA treated tooth. Labels: tp, tooth tip; ub, upper point of base; lb, lower base; ab, attachment bone. D: Graph of measurement means. Error bars = standard deviation. E: XY plot of all measurements. Best fit line is shown (R2 = 0.46; P < 0.0001). Significance tests: ***P < 0.001; ****P < 0.0001; ns = not significant.
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