ZFIN Image: Ma et al., 2015, Fig. 6

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Figure Caption

Fig. 6

MAPK pathway inhibition blocks the separation of the anterior and lateral cristae. (A-L′) MAPKK inhibition represses expression of p-Erk3 and E-cadherin in both jag1b^+/- and jag1b^-/- embryos. Arrows and arrowheads indicate staining of E-Cadherin or p-Erk3. (M-M′′) In jag1b^+/- embryos, treatment with the MAPKK inhibitors CI-1040 (M′) and PD0325901 (M′′) blocks separation of the anterior and lateral cristae. (N-N′′) In jag1b^-/- embryos, the MAPKK inhibitors CI-1040 (N′) and PD0325901 (N′′) block the morphological change of cells in the anterior prosensory domain. Dorsolateral views. Scale bars: 20µm. Anterior towards the left and dorsal upwards.

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Acknowledgments

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