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Fig. 2
The Jak/Stat3 Signaling Pathway Is Necessary for Retina Regeneration
(A) BrdU immunofluorescence shows that the Jak inhibitors P6 and JSI-124 suppress progenitor formation at 4 dpi. The asterisk marks the injury site (needle poke) and arrows point to MG-derived progenitors.
(B) Quantification of BrdU+ progenitors in (A). p < 0.001, n = 4.
(C) qPCR shows that the Jak inhibitors P6 and JSI-124 inhibit reprogramming gene induction at 2 dpi; p < 0.01, p < 0.001; n = 4, 4, and 5 for DMSO, P6, and JSI-124, respectively.
Error bars, SD. Scale bars, 20 µm (A). See also Figure S3.
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