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Fig. S3
Fih-1 regulates endothelial cell proliferation.
Proliferating endothelial cells in control (A and C) or fih-1 MO-injected (B and D) at 55 hpf (A and B) and 72 hpf (C and D). The number of BrdU positive endothelial cells within the intersegmental vessels (ISVs) was significantly increased in fih-1 MO-injected embryos at 55 and 72 hpf, compared to control embryos. Arrows indicate GFP+/BrdU+ endothelial cells in Tg(kdrl:EGFP) transgenic zebrafish (B′′ and D′′). Quantification on the number of GFP+/BrdU+ endothelial cells are shown in E. Asterisks indicate statistical significance (* p<0.005). Error bars, ±SD. n = 6 (55 hpf control), 5 (72 hpf control), 8 (55 hpf fih-1 MO-injected), and 9 (72 hpf fih-1 MO-injected).
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