Fig. 5 Convergence and extension defects are apparent in MZjek. (A,B) Representative photos of live wildtype (A; N=9) and MZjek (B; N=7) embryos at 9 SS. (C) Quantification of the angle of body axis extension over the yolk in wildtype, MZjek and Zkny (***p<0.001). (D,E) Flat-mounts of 10 SS wildtype (D; N=13) and MZjek (E; N=10) embryos stained for krox-20 (hindbrain) and myoD (somite) gene expression. (F) Quantification of the anterior–posterior extent of the myoD expression domain in wildtype versus MZjek (***p<0.001). (G) Quantification of the mediolateral extent of krox20 expression in wildtype versus MZjek (***p<0.001).
Reprinted from Developmental Biology, 387(2), Superina, S., Borovina, A., and Ciruna, B., Analysis of maternal-zygotic ugdh mutants reveals divergent roles for HSPGs in vertebrate embryogenesis and provides new insight into the initiation of left-right asymmetry, 154-166, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.