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Fig. 4
Overexpression of dnRAR blocks pancreatic field specification. (A–D) The results of whole mount in situ hybridization to detect ins and trypsin expression in, dnRAR cre responder transgenic larvae at 72 hpf. Expression of ins and trypsin demonstrates normal pancreatic field specification. (A and B) Negative control larvae (CT). (C and D) Larvae previously injected with cre mRNA at the one-cell stage and displaying the failure of pancreas specification in presence of cre-dependent dnRAR-GFP. Arrows indicate the location of larval pancreata.
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Reprinted from Developmental Biology, 394(1), Huang, W., Wang, G., Delaspre, F., Vitery, M.D., Beer, R.L., Parsons, M.J., Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development, 83-93, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.