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Fig. 6
Legumain MOs inhibit axonal regrowth after SCI.
(A) Representative images of neurons retrogradely labeled in the NMLF and IMRF 6 weeks after SCI. (B) Quantification of biocytin-labeled neuronal profiles in fish that had received legumain MO1 (n = 7 fish), legumain MO2 (n = 6 fish) or CON MO (n = 6 fish). Legumain MO1 and MO2 treatments reduce the numbers of biocytin-labeled neuronal profiles in the NMLF and IMRF when compared with CON MO treatment. Dorsal is up. * P<0.05, one-way ANOVA with Tukey′s post hoc test; mean values ±SEM are shown. Scale bar, 50 μm.
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