ZFIN Image: Jiang et al., 2014, Fig. 5

Image

Figure Caption

Fig. 5

The Jak1/Stat3 pathway is activated during the early stages of hair cell regeneration. (A) In situ hybridization shows that stat3 is increased at 1 and 3 h after neomycin treatment. (B) bmp5 is up-regulated at 1 h after neomycin treatment in situ. (C) Table depicting the status of signaling pathways at different time points after hair cell death. All comparisons (no change, inhibition, or activation) were evaluated relative to untreated control samples. The Wnt, Notch, and Fgf pathways are inhibited immediately after neomycin treatment, whereas the cell cycle and Jak1/Stat3 pathways are activated during the early stages of regeneration. The Wnt and Notch pathways are reactivated at 12 h and 5 h after neomycin treatment, respectively.

Figure Data

Expression / Labeling details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA