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Fig. S1 ROCK inhibitor treated hearts exhibit AV canal defects. (A, B) Confocal projections and (C, D) cross-sectional analyses of 60 hpf Tg(cmlc2:ras-eGFP) hearts reveal that (B, D) ROCK inhibitor (ROCKi) treated zebrafish exhibit cardiac looping and AV canal defects. (E, F) Bar graphs represent cardiomyocyte (E) surface area and (F) morphology/circularity measurements of Tg(cmlc2:ras-eGFP) hearts at 60 hpf. Mean+s.e.m. Studentós t-test, *p<0.05 (n = 12 for control DMSO-treated hearts and n = 12 for ROCK inhibitor treated hearts).
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Reprinted from Developmental Biology, 389, Dickover, M., Hegarty, J.M., Ly, K., Lopez, D., Yang, H., Zhang, R., Tedeschi, N., Hsiai, T.K., Chi, N.C., The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis, 182-91, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.