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Figure Caption
Fig. S1
smoothened signaling acts in the surrounding mesenchyme. (A,B) Confocal cross section of the transcriptional reporter Tg(GBS-ptch2:EGFP)umz23. Phalloidin (red), DAPI (blue). Scale bar: 20 μm. (C) Hh is expressed in the epithelium and binds to ptch in the mesenchyme to activate smo mediated downstream transcription. Thus, smo regulates the epithelium through epithelial-mesenchymal signaling pathways. (D,E) Dorsal view of an in situ hybridization showing αSMA expression in WT and smo mutant embryos at 72 hpf. Arrows point to smooth muscle. Scale bar: 100 μm.
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