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Fig. S4
sfrp1a/5 knockdown reduces Wnt signaling in Tg(TOP:dGFP) embryos. In situ hybridization for eGFP mRNA in the Tg(TOP:dGFP) line shows a pattern of Wnt signaling regionalized in the forebrain and midbrain at 24 hpf (A-B). We note a decrease in domain and intensity of eGFP signal in sfrp1a/5 MO injected embryos (C-D), indicating a decrease in Wnt signaling in these tissues.
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Reprinted from Developmental Biology, 388(2), Holly, V.L., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J., Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development, 192-204, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.