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Fig. 7 obd cells in ventral somite perturb wild-type endothelium: obd acts cell non-autonomously. (A) Transplanted obd somite labeled with rhodamine-dextran in the tail of an unlabeled wild-type embryo at 52 hpf. (B) Angiogram of the same embryo showing normally patterned ISVs in regions of no transplant (or where dorsal obd somite was transplanted) and vascular disorganization in the tail region where obd ventral somite was transplanted (bracket). (C) Overlay of A,B. (D) ISVs composed of wild-type endothelial cells grow mid-somite (borders of the somites are indicated by arrowheads), in the vicinity of rhodamine dextran biotin-labeled obd somite. ISV, intersegmental vessel; nc, notochord; s, somite. Scale bar is 10 μm.