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Fig. 7
Exposure of nlrc3-like Heterozygous Embryos to Systemic LPS Challenge Disrupts Microglia Development
(A) Neutral red staining at 3 dpf shows normal formation of microglia in control uninjected nlrc3-like heterozygous embryos. In contrast, many nlrc3-like heterozygous embryos injected with LPS at 1 and 2 dpf have strongly reduced (6–16 microglia) or eliminated (0–5 microglia) microglia.
(B) Bar graph shows the frequency of loss of microglia in nlrc3-like heterozygous fish injected with LPS, compared with little effect on the wild-type siblings.
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