ZFIN Image: Kamm et al., 2013, Fig. 6

Image

Figure Caption

Fig. 6 Differences in expression driven by human and chimpanzee HAR202 orthologs. (A) Diagram of the transgene structure based on the Tol2 system. Below, fluorescent (B, C, F, and G) and bright field (D, E, H, and I) photomicrographs of selected whole mount transgenic zebrafish embryos expressing the reporter protein EGFP under control of the human (HAR202-Hs) or the chimpanzee (HAR202-Pt) sequences at 24 and 48 hpf. Coronal cryostat sections showing a detail of cells expressing EGFP (J, M, P, and S), cells expressing the early neuronal marker HuC/D (K, N, Q, and T) and the resulting overlay (L, O, R, and U) in the 48 hpf developing zebrafish (sections levels are approximately indicated in G). TeO, tectum opticum; T, midbrain tegmentum; DT, dorsal tegmentum; Po, preoptic region; MO, medulla oblongata; OC, otic capsule; SC, spinal cord; Hi, hypothalamus; Hy, hypophysis.

Figure Data

Expression / Labeling details

Acknowledgments

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