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Fig. 6 Three members of the Notch pathway were downregulated. (A) The graph shows the results of qPCR analyses of her4, mib and Notch1α mRNA levels when ztfpi-2 was knocked down at 24 hpf. Asterisks indicate a significant difference from the Mcon-MO group (Student′s t test, P<0.05). (B) Results of qPCR showed that both her4 and mib were reduced as early as 3 somites stage. ((C), (D)) WISH indicated that her4 and mib were downregulated while ztfpi-2 mRNA could partially recover their expression at 3 somites stage and 25 hpf.
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Reprinted from Developmental Biology, 381(1), Zhang, Y., Wang, L., Zhou, W., Wang, H., Zhang, J., Deng, S., Li, W., Li, H., Mao, Z., and Ma, D., Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development, 38-49, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.