ZFIN Image: Kim et al., 2013, Fig. 1

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Fig. 1

mTORC1 signaling in malignant abdominal tumors in p53^zdf1/zdf1 zebrafish. (A) 1-year-old p53^zdf1/zdf1 mutant fish with prominent abdominal tumor. (B) Hematoxylin and eosin (H&E) staining of a section from an abdominal tumor showing whorls of spindle-shaped cells consistent with an invasive sarcoma. (C,D) Increased expression of mTORC1 downstream effectors phospho-S6 (C) and phospho-4EBP1 (D) in abdominal tumors from p53^zdf1/zdf1 zebrafish. For C and D, red fluorescence is immunosignal and blue is DAPI nuclear stain. M, muscle; T, tumor. Scale bars: 100 μm. Similar findings were seen in abdominal tumors from 10/10 p53^zdf1/zdf1 zebrafish.

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Acknowledgments

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