ZFIN Image: Czopka et al., 2013, Fig. S2

Image

Figure Caption

Fig. S2

Fyn is required for normal myelination

Relates to Figures 4 and 6 and Movie S2.

(A) Images of control (top) and fyn Morpholino (bottom) at 4 days post fertilization (dpf) show that reduction of Fyn function does not cause any gross effects on the general development of the animal (bottom). Scale bar: 1mm.
(B) Confocal images of Tg(mbp:EGFP-CAAX) expressing control (top) and fyn morphant (bottom) animals show that abrogation of Fyn function causes a reduction in myelination. Scale bar: 25μm.
(C) Western blotting of control and fyn Morpholino injected zebrafish embryos shows strong reduction of Fyn protein at 3 dpf.

Acknowledgments

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Reprinted from Developmental Cell, 25(6), Czopka, T., Ffrench-Constant, C., and Lyons, D.A., Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo, 599-609, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell