ZFIN Image: Sorrell et al., 2013, Fig. 1

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Fig. 1

Tcf7l1a and Tcf7l1b restrict CM number. Hearts from (A) control, (B) Tcf7l1a deficient, (C) Tcf7l1b deficient, and (D) Tcf7l1 deficient embryos. Hearts of Tcf7l1a, Tcf7l1b, and Tcf7l1 deficient embryos are enlarged relative to controls. Hearts are frontal views. Red indicates ventricles. Green indicates atria. (E) CM number counts in control (n=20), Tcf7l1a deficient (n=22), Tcf7l1b deficient (n=20), and Tcf7l1 deficient (n=28) embryos. (F) Fold difference in CM number in Tcf7l1 individual and co-depleted embryos. (G) qPCR for myl7 expression. All analyses were at 48 hpf. Single asterisk indicates a statistically significant difference compared to controls. Double asterisks indicate statistically significant difference compared to control, Tcf7l1a deficient, and Tcf7l1b deficient embryos.

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Acknowledgments

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Reprinted from Developmental Biology, 380(2), Sorrell, M.R., Dohn, T.E., D'Aniello, E., and Waxman, J.S., Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish, 199-210, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.