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Fig. S4
DAPT treatment leads to Notch signalling downregulation in regenerating fins and reduces regenerative outgrowth. (A,B) Juvenile fish treated with 50 μM DMSO or DAPT for 3 days. Fin regeneration is impaired by DAPT treatment. (C) Mean length of fin regenerates; DAPT treatment (n=10) decreased regenerate length compared with DMSO-treated fins (n=6); ***P<0.005. (D,E) her6 whole-mount in situ hybridization reveals Notch activity in DMSO-treated fins (D) but not in DAPT-treated fins (E).
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