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Fig. 5, S1 At 33 hpf, severe phenotype embryos (top right) have major malformations in both microvillous and ciliated neurons and often perish, likely reflecting non-specific effects. At 55 hpf (bottom) are shown the same embryos as in Figure 5 (D–F′).
At 55 hpf (bottom) are shown the same embryos as in Figure 5 (D–F′). While there is some recovery of microvillous neurons in ‘mild′ embryos, their numbers remain decreased in comparison to controls. ‘Moderate′ embryos have near complete lack of neural crest-derived microvillous neurons, whereas ciliated neurons are present and project to the olfactory bulb.
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