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Figure Caption
Fig. S3
Rescue of hi2151 Mutant or XAV939 Treatment Phenotypes by EpCAM or Its Subdomains. related to Figure 2
(A–F) In contrast to the wild-type (A), aberrant liver development in hi2151 mutants
(B) can be rescued by either full-length epcam
(C), or epcam ECD-TM (D), or epcam ECD mRNA (E), but not by epcam ICD mRNA (F) as observed at 102 hpf under the Tg(lfabp:GFP) background.
(G–I) epcam mRNA cannot rescue liver phenotypes caused by the XAV939 treatments.
Acknowledgments
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Reprinted from Developmental Cell, 24(5), Lu, H., Ma, J., Yang, Y., Shi, W., and Luo, L., EpCAM Is an Endoderm-Specific Wnt Derepressor that Licenses Hepatic Development, 543-553, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell