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Fig. 5 Microtubule disassembly induces neutrophil polarity and motility in a PI(3)K-independent manner. (A) Microtubule depolymerization with nocodazole reverses F-actin polarity defects caused by PI(3)K inhibition. (B) Microtubule disassembly reverses PI(3)K inhibition-induced migration arrest and enhances neutrophil motility compared with control. n = 66 (DMSO), 64 (LY294002) and 48 (nocodazole, LY294002). *P<0.05, one-way ANOVA with Tukey post-test. Three time-lapse movies were analyzed for data for (B). Scale bar: 10 μm.
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Full text @ J. Cell Sci.