ZFIN Image: Bohnsack et al., 2013, Fig. 1

Image

Figure Caption

Fig. 1

TH regulates early neural crest development. Thraa MO knockdown (decreased TH signaling) inhibited neural crest migration at 24 (B) and 48 hpf (E) vs. control (A, D) in Tg(foxd3::EGFP). Thraa MO knockdown inhibited expression at 24 hpf of crestin in the head (H) and body (K; between somites, arrows) vs. control (G, J). Dio3 MO knockdown (increased TH) in Tg(foxd3::EGFP) embryos inhibited PA (arrowheads) formation at 24 (C vs. A) and 48 hpf (F vs. D). In situ hybridization for crestin demonstrated Dio3 MO knockdown impaired neural crest migration in the head (I) and between somites (L, arrows) at 24 hpf. Asterisk denotes developing eye. Scale bar=50 or 100 µm as indicated.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 373(2), Bohnsack, B.L., and Kahana, A., Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development, 300-309, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.