ZFIN Image: Chu et al., 2013, Fig. 3

Image

Figure Caption

Fig. 3 mpi morphants develop multi-systemic abnormalities. (A) Injection of 6.7 ng of mpi MO results in morphants that are characterized by a small head, microphthalmia, pericardial edema, jaw defects and reduced liver size as visualized in live fish expressing dsRed in hepatocytes [Tg(fabp10:dsRed)] from 30 to 100 hpf. Scale bar: 50 μm. (B) Embryo clutches injected with mpi MO have an average of 15% phenotypically normal embryos as compared with 93% of control embryos. Range from 0–35% normal. P<0.0001 by Fisher′s exact test. Numbers in parentheses under n values indicate the number of experiments. (C) Injection of 6.7 ng of mpi MO results in abnormal liver development. Liver size correlated with severity of phenotype. (D) ‘Phenotype score’ equation. (E) Linear regression analysis shows that phenotype score is inversely correlated with residual Mpi enzyme activity.

Figure Data

Phenotype details

Acknowledgments

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