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Fig. 4 Effect of a human coding polymorphism on zebrafish mRNA rescue of the golden phenotype.
Lateral views of 48-hpf (A and B) wt zebrafish larva (C and D) golb1 zebrafish larva (E and F) golb1 larva injected with full-length zebrafish slc24a5 (wt) mRNA (500 pg) and (G and H) golb1 larva injected with full-length zebrafish slc24a5 mRNA with a single nucleotide change (500 pg), coding for the orthologous human derived A111T allele. Scale bars in (A, C, E, G) 150 μm, (B, D, F, H) 400 μm.
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