ZFIN Image: Filippi et al., 2012, Fig. S5

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Figure Caption

Fig. S5

Dorso/ventral patterning defects in the prethalamus of arx morphants. WISH was performed to detect pax6a (A,B), lhx1a (C,D) and nkx2.2a (E,F) expression in arx morphants at 72 hpf. Arx knock-down results in the specific reduction of pax6a and lhx1a prethalamic domains (arrows in B and D, respectively), and in the increase of prethalamic nkx2.2a expression (arrowhead in E). Lateral views of the heads are shown, anterior is to the left. Abbreviations: HB, hindbrain; Hyp, hypothalamus; n, notochord; T, tectum; TC, telencephalon; Th, thalamus. Scale bars in A (applies to A-D) and in E (applies to E,F) = 100 μm.

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Reprinted from Developmental Biology, 369(1), Filippi, A., Jainok, C., and Driever, W., Analysis of transcriptional codes for zebrafish dopaminergic neurons reveals essential functions of Arx and Isl1 in prethalamic dopaminergic neuron development, 133-149, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.