ZFIN Image: Liu et al., 2012, Fig. 1

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Figure Caption

Fig. 1 Mutation of Git1 binding residues in βPix or knockdown of Git1 leads to hemorrhage. A) Expression of mutant βPix lacking residues important for Git1 binding (βPix IP/EG) leads to increased hemorrhage in wild type vessels, and in bbh^m292 mutants. B) Knockdown of Git1 by either a Git1^i1e2 or Git1^ATG morpholino leads to increased hemorrhage as compared to wild type embryos. C) Wild type embryo at 48 hpf. D) Git1^i1e2 morphant shows hemorrhage (arrow) and hydrocephalus (star).

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Acknowledgments

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Reprinted from Developmental Biology, 363(1), Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J., betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8, 95-105, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.