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Fig. 4 Foxg1 Functions Downstream of Shh Activity to Induce Subpallial Character(A–P) The markers analyzed are indicated on the left of each row. The identity of the embryos is indicated on top of each column. (A–H) Expression of (A–D) nkx2.1b and (E–H) tbr1 when shh is overexpressed in (C and G) WT or in (D and H) foxg1 morphants, compared to (A and E) WT or (B and F) foxg1 morphants. (I and J) Foxg1 expression in the (I) 5ss control or in (J) embryos treated with cyclopamine at bud stage. (K–P) Effects of cyclopamine treatment at the bud stage in (L and O) WT or (M and P) foxg1-overexpressing embryos on dlx2 and islet1 compared to (K and N) untreated WT. (K–M) Telencephalon is highlighted by tbr1 expression in red (insets).
Reprinted from Developmental Cell, 16(4), Danesin, C., Peres, J.N., Johansson, M., Snowden, V., Cording, A., Papalopulu, N., and Houart, C., Integration of telencephalic Wnt and hedgehog signaling center activities by Foxg1, 576-587, Copyright (2009) with permission from Elsevier. Full text @ Dev. Cell