ZFIN Image: Chen et al., 2012, Fig. S5

Image

Figure Caption

Fig. S5

Over-expression of sox11b and sox19b causes a cyclopia phenotype. Control embryos (A), and embryos over-expressing sox11b (B), and sox19b (C) at 24hpf. In situ hybridisation analysis indicates that as compared to control embryos the chordin expression domain is expanded in sox19b injected embryos (D). In situ hybridisation (E) for dlx3b reveals that convergent extension is perturbed in embryos injected with sox19b mRNA. As a consequence, the formation of axial mesoderm is altered in sox19b mRNA injected embryos as visualised by ntl expression (F). As compared to the control, cyc expression is reduced (G) in embryos over-expressing sox19b at the 75% epiboly stage (upper panel, dorsal view; bottom panel, lateral view). D- dorsal in D and F.

Acknowledgments

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Reprinted from Mechanisms of Development, 129(1-4), Chen, Y.Y., Harris, M.P., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M., Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes, 13-23, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.