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Figure Caption
Fig. S5 Mxtx2 binds to YSL genes, related to Figure 6
(A) Mxtx2-Myc induces ectopic YSL transcription. Lateral view of embryos injected with control 100pg GFP mRNA or 100pg mxtx2-Myc mRNA at the 1-cell stage.(B) Mxtx2 binding profiles at gpr137bb, mxtx1, otop1, znf503, gata3, cebpa, hnf1ba, and slc40a1 loci. ChIP-Seq data are shown in reads per million with the y-axis floor set to 2 reads per million.
(C) Binding profiles for Nanog-like and Mxtx2 at the nanog-like and snai1a loci. Many loci are co-occupied by both transcription factors.
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Reprinted from Developmental Cell, 22(3), Xu, C., Fan, Z.P., Müller, P., Fogley, R., Dibiase, A., Trompouki, E., Unternaehrer, J., Xiong, F., Torregroza, I., Evans, T., Megason, S.G., Daley, G.Q., Schier, A.F., Young, R.A., and Zon, L.I., Nanog-like Regulates Endoderm Formation through the Mxtx2-Nodal Pathway, 625-238, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell