ZFIN Image: Martin et al., 2012, Fig. S4

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Figure Caption

Fig. S4

Wnt signaling is continuously required for fate decisions throughout body formation, related to Figure 3

(A) Control or (B) HS:TCFΔC cells were transplanted into the ventral margin of shield stage unlabeled wildtype hosts and heat-shocked at the 8-somite stage. (B) As with earlier stage heat-shocks, the posterior-most cells transfate to spinal cord (arrowhead) while more anterior cells contribute normally to somites (arrow). The ventral posterior-most cells also transfate to vascular endoethelium. (C-F) sox2 expression in 24 hour old control or HS:dkk1-EGP embryos. (C) At 24 hours, sox2 expression is not present in the posterior-most region of the embryo. Heat-shocking embryos at the (D) 8-somite, (E) 14-somite, or (F) 20-somite stage causes an expansion of sox2 positive tissue (arrowheads).

Acknowledgments

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Reprinted from Developmental Cell, 22(1), Martin, B.L., and Kimelman, D., Canonical Wnt Signaling Dynamically Controls Multiple Stem Cell Fate Decisions during Vertebrate Body Formation, 223-232, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell