ZFIN Image: Ulitsky et al., 2011, Fig. 2

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Figure Caption

Fig. 2

Expression of Zebrafish lincRNAs (A) Whole-mount in situ hybridizations of selected lincRNAs. Control experiments using sense probes for selected lincRNAs were also performed (Figure S2). (B) Expression levels of lincRNA and protein-coding genes evaluated using RNA-Seq results from ten stages/tissues. Plots indicate the median, quartiles, and 10^th and 90^th percentiles. RPKM is reads per kilobase per million reads. (C) Correlations between levels of neighboring transcripts. For each gene, the Spearman correlation between its expression profile (across ten stages/tissues) and that of the closest protein-coding gene was determined, and the average is plotted for the lincRNA and coding genes. Error bars are 95% confidence intervals based on 1,000 random shuffles of lincRNA positions. See also Figure S2 and Table S4.

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Acknowledgments

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Reprinted from Cell, 147(7), Ulitsky, I., Shkumatava, A., Jan, C.H., Sive, H., and Bartel, D.P., Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution, 1537-1550, Copyright (2011) with permission from Elsevier. Full text @ Cell