ZFIN Image: Nachtrab et al., 2011, Fig. 4

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Figure Caption

Fig. 4 GSK3 Inhibition Rescues Fin Regeneration

(A) Blastemal proliferation in anterior portions of 4 dpa pectoral fin regenerates from vehicle- and BIO-treated males, assessed by H3P staining. Arrowheads indicate amputation plane.

(B) Treatment with 100 nM BIO for 4 days after amputation increased male anterior blastemal proliferation by 56%. Female blastemal proliferation was not affected by BIO (n = 26?30 males, n = 12 females). ^*p < 0.001 by Student′s t test.

(C and D) Four days of BIO or FEN treatment after amputation, followed by 3 days without treatment, increased male anterior regenerate lengths by 47% and 48%, respectively, over vehicle alone (n = 22?24 BIO, n = 8 FEN). ^*p < 0.001 by Student′s t test.

Acknowledgments

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