ZFIN Image: Nguyen et al., 2011, Fig. 5

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Figure Caption

Fig. 5 Activation of the Wnt–β-catenin pathway during kras^V12 liver tumorigenesis. Representative immunohistochemical liver sections from WT zebrafish as the control and kras^V12 transgenic fish with liver hyperplasia and carcinoma are shown. (A) Immunohistochemistry for β-catenin showing an increasing nuclear localization of β-catenin during HCC progression. (B) Immunohistochemistry for E-cadherin showing loss of membranous E-cadherin expression during tumor growth. (C) Immunohistochemistry for Ki67 showing a high expression level of Ki67 in cell nuclei, which increased from hyperplasia to carcinoma.

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Acknowledgments

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