ZFIN Image: Takeuchi et al., 2007, Fig. 1

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Figure Caption

Fig. 1

Baf60c regulates LR asymmetry at the node. (A) Smarcd3 knockdown caused randomized heart looping. Red arrows indicated the direction of heart looping. (B) Histogram shows the percentage of control (siTbx20), Smarcd3 knockdown (siSmarcd3), and Rbpsuh ^-/- mutant embryos with rightward, linear, and leftward heart morphologies. (C–E) Expression of LR regulators in wild-type (wt) and Smarcd3 knockdown (Si) embryos. Shown are Lefty1/2 (C), Pitx2 (D) at E8.25, and Nodal (E) at E7.75. (F–I) Decreased expression of Notch1 and increased expression of Dll1 in siSmarcd3 embryos. (J–O) Smarcd3 expression in perinodal cells and coexpression with Nodal by in situ hybridization on consecutive sections at E7.75 (O). Red lines in K show the plane of sections shown in L and M.

Acknowledgments

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