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Fig. 3
APs recorded from explanted embryonic zebrafish hearts. (a) (Upper) Representative spontaneous APs recorded from wild-type (WT) atrium (Left) and ventricle (Right) at 48 hpf. (Lower) Spontaneous APs recorded from kcnh2s290 mutant atrium (Left). Recordings of transmembrane voltage (V m) from mutant ventricle (Right) revealed marked membrane depolarization and the absence of action potentials. (b) V m recorded from kcnh2s290 mutant ventricle. Intracellular injection of hyperpolarizing current (-100 pA) caused membrane hyperpolarization and allowed for the generation of spontaneous APs.
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Full text @ Proc. Natl. Acad. Sci. USA