ZFIN Image: Gutierrez et al., 2011, Fig. 2

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Figure Caption

Fig. 2

Osteosarcoma development in a rag2:myr-mAkt2-injected, p53-homozygous mutant zebrafish. (A and B) A p53-homozygous mutant zebrafish injected with the rag2:myr-mAkt2 expression construct developed a solid lobulated mass at the base of the dorsal fin. Note that the image shown in A consists of merged adjacent photomicrographs. (Scale bars, 1 mm.) (C and D) H&E-stained sections at low and high magnification, respectively, demonstrate a mass consisting predominantly of osteoid matrix interspersed with large malignant cells with pleomorphic nuclei, features that in humans are diagnostic of osteoblastic osteosarcoma. (Scale bars, 100 μm.)

Acknowledgments

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