ZFIN Image: Perlin et al., 2011, Fig. 4

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Fig. 4

Nrg1 type III is required in neurons and ErbB receptors are required in all Schwann cells. (A) Wild-type cells marked with a Texas Red-Dextran lineage tracer were transplanted into nrg1^z26 mutant hosts carrying the Foxd3:GFP (green) transgene at the blastula stage. (B-B2) Lateral view of genetic chimera generated by transplanting wild-type cells (red) into the nrg1^z26 mutant. Arrowheads point to nrg1^z26 mutant Schwann cells, which have migrated along axons (arrows) of wild-type neurons (asterisks). Open arrowhead marks a wild-type Schwann cell. (C) Wild-type cells carrying the Foxd3:GFP transgene (green) labeled with a Texas Red-Dextran lineage tracer were transplanted into erbb^st50 mutant hosts also carrying the Foxd3:GFP transgene at the blastula stage. (D-D2) Lateral view of genetic chimera generated by transplanting wild-type cells (red) into the erbb^st50 mutant. All Schwann cells (arrowheads) are labeled by the wild-type lineage tracer. Anterior is to the left and dorsal is up in all images; embryos were genotyped after imaging. Scale bars: 50 μm.

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