ZFIN Image: Lu et al., 2011, Fig. 4

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Figure Caption

Fig. 4 Sfrp1a and Frzb regulate the activation of the maternal Wnt/β-catenin signaling pathway. Expression pattern of chordin are shown in wild type (A) or in embryos injected with 4 ng (B), 5.5 ng (C), and 7 ng (D) of Frzb morpholinos. (E) At the two-cell stage Sfrp1a and Frzb prevent activation of the maternal Wnt pathway in the blastomeres, whereas the dorsal determinant, Wnt8a, is transported from the vegetal pole toward the blastomeres in a microtubule-dependent manner. At the high stage (immediately after the midblastula transition), Wnt8a translated from these transported mRNAs stimulates the canonical β-catenin pathway. Sfrp1a and Frzb are required to limit this activation to the cells receiving the highest level of stimulation.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA