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Fig. 4
Restoring Spadetail significantly rescues the spt phenotypes. (A) A genetic construct was incorporated into the zebrafish genome by Tol2-mediated transgenesis. The spt and eGFP genes were placed downstream of a bi-directional heat shock-sensitive promoter. (B) Expressing spt from this construct partially restored expression of tbx24 in spt morphant embryos. (C) Significant phenotypic rescue was also observed by inducing transgene expression early in gastrulation. Arrowheads mark the position of the first and last formed somite in each embryo.
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Reprinted from Developmental Biology, 354(1), Row, R.H., Maître, J.L., Martin, B.L., Stockinger, P., Heisenberg, C.P., and Kimelman, D., Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail, 102-110, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.