ZFIN Image: Waxman et al., 2011, Fig. 8

Image

Figure Caption

Fig. 8

Zebrafish dnRARab does not act as a transcriptional repressor in zebrafish embryos. (A–F) Uninjected control embryos. (G–L) Embryos injected with zebrafish dnrarab mRNA appear equivalent to uninjected control embryos. (M–R) Injection of human dnrara mRNA causes phenotypes consistent with loss of RA signaling, including enlarged hearts (arrow in M), loss of pectoral fin (N), loss of rhombomere 5 (arrows in O and P), and loss of endogenous target gene expression (arrows in Q and R). Phenotypes induces by injection of the human dnrara mRNA are similar to, if not stronger than, those induced when the human dnRARa is expressed from a heat-shock inducible transgene (Waxman et al., 2008). Cktl of probes is the same as in Fig. 6. (A–C, G–I, M–O) Images are lateral views with dorsal to the right. (D–F, J–L, P–R) Images are dorsal views, anterior up.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 352(1), Waxman, J.S., and Yelon, D., Zebrafish retinoic acid receptors function as context-dependent transcriptional activators, 128-140, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.