ZFIN Image: Lupo et al., 2011, Fig. s8

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Figure Caption

Fig. s8

Exogenous RA increases expression of VR/OS and POM genes. (A and B) Lateral views of eyes from 25- to 29-hpf hybridized embryos treated with DMSO or 0.125–0.5 μM RA from 3s. (A) In the control eyes, dhrs3a, nlz2, dact1, and itgA5 are expressed in VR/OS cells (arrowheads). nlz2 also has a restricted expression domain in the dorsal retina (triangle). RA treatments cause up-regulation of all these genes in the dorsal retina. Arrows point to partial dact1 and itgA5 up-regulation in the central retina region at lower RA doses. Dashed circles highlight the eye region in treated embryos. (B) RA treatments increase foxC1a, nlz1, lmx1b1, and pitx2 expression in anterior POM (triangles). The RA-treated embryos also show dose-dependent decrease in nlz1 and lmx1b1 expression in ventral POM (arrowheads). Arrows point to up-regulation of nlz1 in the dorsal eye region of the RA-treated embryos.

Acknowledgments

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