ZFIN Image: Klein et al., 2011, Fig. S12

Image

Figure Caption

Fig. S12 Development of the ventral pancreas in control and Nav3a morphants. Sox17:GFP^s870 embryos injected with control morpholino or Nav3a-ATG morpholino were analyzed for Prox1 expression in the ventral pancreas. (A) In controls, the ventral pancreatic bud develops from the foregut endoderm between 38 and 44 hpf. Ventral-dorsal axis is color coded (red, ventral; blue, dorsal). Dashed lines indicates the developing pancreas. (B) Prox1 immunofluorescence at 40 hpf shows that Nav3a is essential for ventral pancreatic budding and Prox1 activation within the ventral pancreas. Note reduced Prox1 expression in pancreatic region of Nav3a morphants. The percentage of embryos exhibiting a similar phenotype as displayed in the figure, is indicated in the lower right corner.

Acknowledgments

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