ZFIN Image: Klein et al., 2011, Fig. S8

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Figure Caption

Fig. S8 Depletion of Wnt2bb, BMP or FGF receptor-1 signalling reduced Hhex expression. Sox17:GFP^s870 embryos injected with control morpholino (left panels), Wnt2bb morpholino (upper right panel), or embryos obtained from outcrossing of hemizygous Tg(hsp70l:dnBmpr-GFP) (middle right panel) or Tg(hsp70l:dnfgfr1-GFP) (lower right panel) were examined for hhex expression at 48 hpf by in situ hybridization. Depletion of wnt2bb, BMP-R1 and FGF-R1 resulted in reduced hhex expression, indicating that the experimental setup resulted in impaired hepatoblast specification. The percentage of embryos exhibiting a similar expression pattern is indicated in the lower right corner (n=10-20/group). All images are dorsal views. White arrowheads indicate liver bud. Black arrowheads indicate the pancreatic bud.

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