ZFIN Image: Padanad et al., 2011, Fig. 5

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Figure Caption

Fig. 5 pax2/8 regulates otic expression of fgf24. (A, C, F) fgf24 expression in the otic placode in control embryos at 11 hpf (A), 13 hpf (C) and 18 hpf (F). (B, D, G) fgf24 expression in pax8 morphants at 11hpf (B), 13 hpf (D) and 18 hpf (G). Expression of fgf24 is lost from preotic placodes in pax8 morphants at 11 hpf (B) and is reduced in pax8 morphants at 13 hpf (D) and 18 hpf (G). (E, H) noi (pax2a) mutants co-injected with pax8-MO and pax2b-MO showing loss of otic expression of fgf24 at all time points. Expression in pharyngeal (pa) arches and the otic vesicle (ov) is indicated. Images show dorsal views with anterior to the top (A–E); lateral views with anterior to the left and dorsal to the top (F–H).

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Acknowledgments

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Reprinted from Developmental Biology, 351(1), Padanad, M.S., and Riley, B.B., Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24, 90-98, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.