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Figure Caption
Fig. s1
(A) heg in situ hybridization shows weak or no detectable expression in the uninjured ventricle. Scale bar = 100 μm (A-C).
(B) heg is induced by 3 hours post-amputation (hpa) in endocardial cells throughout the ventricle (and atrium, not shown).
(C) raldh2 in situ hybridization at 1 hpa, indicating induction in many atrial endocardial cells, but fewer ventricular endocardial cells. The injured ventricular apex is marked by an asterisk.
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Reprinted from Developmental Cell, 20(3), Kikuchi, K., Holdway, J.E., Major, R.J., Blum, N., Dahn, R.D., Begemann, G., and Poss, K.D., Retinoic Acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration, 397-404, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell