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Fig. 4 Genetic interaction between uhrf1 and dnmt1 during lens development. (A) 5 dpf histology from uhrf1+/+; dnmt1+/+, (B) uhrf1+/-; dnmt1+/-, and (C–E) uhrf1-/-; dnmt1-/- embryos. No compound heterozygous eye phenotype is observed (B). Lens defects in uhrf1-/-; dnmt1-/- double mutants are no more severe than those in either of the single mutants, and range from mild (C) to severe (D). uhrf1-/-; dnmt1-/- double mutants with severe body morphology (E) do not have more severe lens phenotypes. Scale bars are 80 μm.
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Reprinted from Developmental Biology, 350(1), Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M., Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens, 50-63, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.